SHRAMAHARA MAHAKASHAYA OF CHARAKA SAMHITA – A PROMISING SUPPLEMENT FOR IMMUNOMODULATION – A SYSTEMATIC REVIEW

Authors

  • K N A Dharmasena 1. MD scholar, Postgraduate department of DravyagunaVigyan,National Institute of Ayurveda, Jaipur Author
  • A Ramamurthy 2. Professor, Postgraduate department of DravyagunaVigyan,National Institute of Ayurveda, Jaipur Author
  • Joshi Krutika 3. Lecturer, Postgraduate department of DravyagunaVigyan, National Institute of Ayurveda, Jaipur Author
  • Gaurav Sahrma 4. Pharmacologist, Postgraduate department of DravyagunaVigyan, National Institute of Ayurveda, Jaipur Author

DOI:

https://doi.org/10.48165/

Keywords:

–Immuno-modulation, anti-fatigue formula, shramahara mahakashaya

Abstract

Immuno-modulation or modification of the immune  responses towards wellbeing is incorporated as vyadhik shamatva, swasthya (wellbeing), bala(strength) and ojas in  Ayurveda. Shrama (fatigue) is the main feature of balakshaya  (Strength depletion), ojahkshaya (condition of depleting  immunity) as well as rasa, asthi and shukradhatu kshaya  (tissue depletions). Thereby, shrama and vyadhik shamatva 

have a coexisting relation. Acharya Charaka has collectively  mentioned 10 drugs as shramahara mahakashaya which  works effectively in shrama. Ingredients of shramahara  mahakashaya are rich in nutrients, antioxidants and also have proven effects on anxiety, and in  immuno-modulation. Hence, this systematic review has been carried out to find the efficacy of  shramahara mahakashaya in immuno-modulation. The study was carried out using thorough  analysis of various Ayurveda classical texts as well as available modern literature and collected  data & observations were presented in a scientific manner. The review will be beneficial to 

understand and to modify the host immunity according to Ayurveda concepts.  

Downloads

Download data is not yet available.

References

Baylor College of medicine, Texas: university. Emerging infectious diseases [internet].[accessed on 03.09.2019] available from:

https://www.bcm.edu/departments/molecular-virology-and-microbiology/emerging infections-and-biodefense/emerging-infectious-diseases

Mrthy SKR. Sushruta samhita (Text. English translation, notes, appendices, and index),volI. Re-print. varanasi: Chaukambha Orientalia;2012. 1.P- 8

Sri Taranatha Tarka vachaspati. Vachaspatyam (A comprehensive Sanskrit Dictionary).Varanasi-1:Chaukhambha Sanskrit Series;1962.P- 2362.

Yadavji Trikamji Acharya .Charaka Samhita, Revised by Charaka and Dridhabala with the Ayurveda dipika commentary of Chakrapani datta. 5th edition. New Delhi: Munshiram Manoharlal Pvt Ltd;1992. P-138.

YadavJi TrikamJi. Sushruta samhita with Nibandha sangraha commentary of Dalhana. Varanasi. Chaukambha Sanskrit sansthan, Re-print. 2014.P-470

Shrama R.K, Dash B. Charaka Samhita (text with English translation &critical exposition based on Cakrapani Datta’s Ayurveda Dipika .Vol.1.Varanasi:Chowkamba Sanskrit series office;2019.P-427

Shrama R.K, Dash B. Charaka Samhita(text with English translation &critical exposition based on Cakrapani Datta’s Ayurveda Dipika .Vol.1.Varanasi:Chowkamba Sanskrit series office;2019.P-565

Shrama R.K, Dash B. Charaka Samhita(text with English translation &critical exposition based on Cakrapani Datta’s Ayurveda Dipika.Vol.III. Re-print. Varanasi: Chowkamba Sanskrit series office;2019.2018.P-162

Mrthy SKR. Sushruta samhita (Text. English translation, notes, appendices, and index), vol I. Re-print. varanasi: Chaukambha Orientalia;2012.Sutra.P-104.

Maharshi Sushruta. Sushruta Samhita. Vol I [KK Thakaral. Trans].Varanasi: Chaukambha Orientalia E- Samhita). 2016. P-168-169

Yadavji Trikamji, Narayana Ram, Sushruta Samhita of Sushruta with the nibandha sangraha commentary of Sri Dalhana acharya, Varanasi: Chaukambha Sanskrit Santhan; 2013. P-71

Tripati B. Ashtanga hrdayam of Srimadha vagbhata edited with Nirmala Hindi commentary along with special deliberation etc.New Delhi, Chaukambha Sanskrit pratishthan.2019;P-168

Shrama R.K, Dash B., Charaka Samhita (text with English translation &critical exposition based on Cakrapani Datta’s Ayurveda Dipika.Vol.1.Varanasi: Chowkamba Sanskrit series office;2019. P-221

Shrama R.K, Dash B., Charaka Samhita (text with English translation &critical exposition based on Cakrapani Datta’s Ayurveda Dipika.Vol.1.Varanasi:Chowkamba Sanskrit series office;2019. P.98

Shrama R.K, Dash B. Charaka Samhita (text with English translation & critical exposition based on Cakrapani Datta’s Ayurveda Dipika.Vol.1.Varanasi:Chowkamba Sanskrit series office;2019.P-68-69

Sharma R.K, Dash B. Charaka Samhita (text with English translation & critical exposition based on Cakrapani Datta’s Ayurveda Dipika .Vol.1.Varanasi: Chowkamba sanskrit series office;2019. P.101

Manju K, Devi D. Role of rasayana as immunomodulator in diseases. International Ayurvedic Medical Journal. 2015 Aug;3(8):2536-2543

Yadavji Trikamji, Narayana Ram, Sushruta Samhita of Sushruta with the nibandha sangraha commentary of Sri Dalhana acharya. Varanasi: Chaukambha Sanskrit Santhan; 2013. P- 470

Adrianne Bendich. Physiological role of antioxidants in the immune system. Journal of dairy science. 1993 Sep; 76(9):2789-2794

Mahajon B.An experimental evaluation of anti-fatigue activity of Shramahara mahakashaya and its applicability in sports [PhD thesis].Post graduate department of Dravyguna Vigyana, National Institute of Ayurveda, Jaipur. Dr. Sarvaepalli Radhakrishnan Rajasthan Ayurveda University.2018

Mahajon B., Rama Murthy A., Relevance of shramahara mahakashaya (An anti-fatigue formulation) in sports medicine2018:Journal of scientific innovation and research,2018;7(1):15-17

Sharma R.K, Dash B., Charaka Samhita (text with English translation &critical exposition based on CakrapaniDatta’s Ayurveda Dipika.Vol.1.Varanasi:Chowkamba Sanskrit series office;2019.P.26-27

Sharma R.K, Dash B. Charaka Samhita (text with English translation &critical exposition based on Cakrapani Datta’s Ayurveda Dipika .Vol.1.Varanasi: Chowkamba sanskrit series office;2019. P.101

Yadavji Trikamji, Narayana Ram, Sushruta Samhita of Sushruta with the nibandha sangraha commentary of Sri Dalhana acharya. Varanasi: Chaukambha Sanskrit Santhan; 2013. P-71

Sharma R.K, Dash B. Charaka Samhita (text with English translation & critical exposition based on Cakrapani Datta’s Ayurveda Dipika .Vol.V.Varanasi: Chowkamba sanskrit series office;2019. P.26-27

Mukherjee S, Das SK, Vasudevan DM. Dietary grapes (Vitis vinifera) feeding attenuates ethanol-induced oxidative stress in blood and modulates immune functions in mice. Indian Journal of biochemistry and biophysics. 2012 Oct;49(5):379-85

Karasawa K, Uzuhashi Y, Hirota M, Otani H. A Matured Fruit Extract of Date Palm Tree (Phoenix dactylifera L.) Stimulates the Cellular Immune System in Mice.Journal of Agricultural and Food Chemistry. 2011 Sep; 59(20):11287-93,DOI: 10.1021/jf2029225

Singh MK, Das BK, Patidar P. The effect of methanolic extract of Buchanania lanzan Spreng seeds on hematological indices. Indian Journal of Pharmacology. 2016;48(2): 214-215

Chen J, Liu X, Li Z, Qi A, Yao P, Zhou Z, Dong TTX., Tsim KWK. A Review of Dietary Ziziphus jujuba Fruit (Jujube): Developing Health Food Supplements for Brain Protection. Evidence-based complementary and alternative medicine.2017 June 7

(3019568):10

Laily N, Harahap AR , Aji GK, Sukarti I , Ascobat P, Wijayanti RDE. Potential Use of Pomegranate (Punica granatum) Extract as an Immune-Stimulant Based on in vitro and in vivo Models. Mal J Nutr. 2016; 22(2): 279 – 287

Yang XM, Yu w, Ou ZP, Ma HL, Liu WM, Ji Xl. Antioxidant and immunity activity of water extract and crude polysaccharide from Ficus carica L. fruit. Plants food humnutri.. 2009 Jun;64(2):167-73

Singh S, Yadav AK. Evaluation of immunomodulatory activity of Grewia asiatica in laboratory animals. Journal of Chemical and Pharmaceutical Research, 2014, 6(7):2820- 2826

Awais A, Akhtar M, Muahmmad M, UlHaq A, Anwar MI. Immunotherapeutic effects of some sugar cane (Saccharumofficinarum L.) extracts against coccidiosis in industrial broiler chickens. Experimental parasitology. 2011 Jun;128(2):104-10. doi: 10.1016/j.exppara.2011.02.024. Epub 2011 Feb 24.

Han L, Meng M, Guo M, Cheng D, Shi L, Wang X, Wang C. Immunomodulatory activity of a water-soluble polysaccharide obtained from highland barley on immunosuppression mice models. Food & Function.2018 Dec;10 (1):DOI: 10.1039/C8FO01991F

Yang LC, Hsieh CC, Lin WC. Characterization and immunomodulatory activity of rice hull polysaccharides. Carbohydrate Polym. 2015 Jun 25;124:150-6. doi: 10.1016/j.carbpol.2015.02.025.

Sharma R.K, Dash B., Charaka Samhita(text with English translation &critical exposition based on Cakrapani Datta’s Ayurveda Dipika.Vol.II.Varanasi:Chowkamba sanskrit series office;2018. P.420-421

Downloads

Published

2019-11-01

How to Cite

Dharmasena, K. N. A., Ramamurthy, A., Krutika, J., & Sahrma, G. (2019). SHRAMAHARA MAHAKASHAYA OF CHARAKA SAMHITA – A PROMISING SUPPLEMENT FOR IMMUNOMODULATION – A SYSTEMATIC REVIEW . International Research Journal of Ayurveda & Yoga, 2(5), 80-94. https://doi.org/10.48165/