Therapeutic Appraisal of Phalatrikadi Yoga with Lekhaniya Mahakashaya in Medoroga w.s.r. to Metabolic Syndrome: A Review.
DOI:
https://doi.org/10.48165/IRJAY.2023.6416Keywords:
Ayurveda, Medoroga, Metabolic Syndrome, Lekhaniya Mahakashaya, Phalatrikadi YogaAbstract
Santarpanottha Vikaras (diseases due to excessive nutrition) are increasing in current era due to faulty lifestyle. Medodushti (disorders of fat metabolism) serves as one of the important etiological factors in most of these disorders including dyslipidaemia, obesity, metabolic syndrome etc. Obesity and Metabolic syndrome (MS) are interconnected disorders having global prevalence, which are associated with physiological, biochemical, clinical and metabolic abnormalities. Both disorders directly influence the risk of cardiovascular disease (CVD) and diabetes mellitus. MS is considered as a first order risk factor for atherothrombotic complications. Pharmacodynamic attributes i.e., Tikta, Katu, Kashaya Rasa, Laghu, Ruksha, Tikshna Guna and Ushna Veerya, Katu Vipaka have individual effect in obesity. Katu Vipaka is having more significant influence in producing Medohara, Lekhana and Karshana karma which is important for management of obesity. It will also help in selection of drugs for the management of Medoroga. Overall, the drugs having dominance Kaphavata shamaka, Dipana, Pachana (digestion), Srotoshodhana (channel cleansing), and Medohara (lipolytic) properties are found to be effective in the management of Medoroga w.s.r. Metabolic Syndrome. In this context, Ayurvedic formulation is selected to laid down an emphasis on its therapeutic potential based on Ayurvedic pharmacodynamic and contemporary work done by the researchers of biomedical sciences.
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References
Scott M. Grundy, James I. Cleeman, Stephen R. Daniels, Diagnosis and Management of the Metabolic Syndrome, An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement, Circulation. 2005; 112:2735-2752, DOI: 10.1161/CIRCULATIONAHA.105.169404
Krishnamoorthy Y, Rajaa S, Murali S, Rehman T. Prevalence of metabolic syndrome among adult population in India: A systematic review and meta-analysis. Oct, 2020; PLOS ONE 15(10): e0240971. https://doi.org/ 10.1371/journal.pone.0240971
Mukhra R, Kaur T, Krishan K, Kanchan T. Overweight and Obesity: A major concern for health in India. Clin Ter 2018; 169 (5):e199-201. doi: 10.7417/CT.2018.2078
Kaur J. A Comprehensive Review on Metabolic Syndrome, Hindawi Publishing Corporation Cardiology Research and Practice Volume 2014, Article ID 943162, http://dx.doi.org/10.1155/2014/943162.
Meenu, Pandey AK, Bihari K, Role of Ama in the pathogenesis and management of Diseases: A Review. WJPR, Vol 10, Issue 13, 2083-2090, Oct 2021.
Singh J, Pandey AK. Clinical Evaluation of Pushkaramula (Inula racemosa) Capsule in the patients of metabolic syndrome” International Journal of Medicine and
Pharmaceutical Sciences (IJMPS) ISSN(P): 2250-0049; ISSN(E): 2321-0095, Vol. 4, Issue 2, Apr 2014, 9-20. 7. Pandey R. Priyasiddhida Hindi Commentary on Yogaratnakara, Chapter 40 Medorogadhikara, Ver.16 Varanasi: Chaukhamba Vishva Bharati; 2019. p. 593. 8. Charak Samhita, Chikitsasthana, Vatavyadhi Chikitsa Adhyaya 4/9. Available from: http://niimh.nic.in/ebooks/echarak. [Last accessed on 2022 Apr 20]
Sharma PV. Dravyaguna-vijnan, Vol-II, Varanasi, India: Publisher Chaukhambha Bharati Academy, reprint 2011. 10. The Āyurvedic Pharmacopeia of India, part 1, vol.1-6. 11. Rathinamoorthy R, Thilagavathi G. Terminalia Chebula (Haritaki) - Review on Pharmacological and Biochemical Studies, International Journal of PharmTech Research, Jan March 2014, CODEN (USA): IJPRIF, Vol.6, No.1, pp 97- 116, ISSN: 0974-4304
Singh MP, Gupta A, Siddhraj S. Ethno and Modern Pharmacological Profile of Baheda (Terminalia bellerica): A Review, The Pharmaceutical and Chemical Journal, 2018, 5(1):153-162, ISSN: 2349-7092
Akhtar SM, Ramzan A, Ali A, et al. Effect of Ᾱmalakī fruit (Emblica officinalis (Gaertn.) on blood glucose and lipid profile of normal subjects and type 2 diabetic patients. International journal of Food sciences and nutrition.2011; 62(6): 609-16p
Ebrahimzadeh V, Malek MA. Javadivala, Z, Mahluji S, Zununi VS, Ostadrahimi A. (2018). A systematic review of the anti-obesity and weight lowering effect of ginger (Zingiber officinale Roscoe) and its mechanisms of action. Phytotherapy research: PTR, 32(4), 577–585. https://doi.org/10.1002/ptr.5986
Singh S, Priyadarshi A, Singh B, Sharma P. Pharmacognostical and phytochemical analysis of Pippali (Piper longum Linn.). The Pharma Innovation Journal 2018; 7(6): 286-289
Turrini E, Sestili P, Fimognari C. Overview of the Anticancer Potential of the "King of Spices" Piper nigrum and Its Main Constituent Piperine. PMID: 33256185, PMCID: PMC7761056
DOI: 10.3390/toxins12120747
Lemaure B, Touché A, Zbinden I, Moulin J, Courtois D, Macé K, et al. Administration of Cyperus rotundus tubers extract prevents weight gain in obese Zucker rats. Phytother Res 2007; 21:724-30.
Madhavi M, Mallika G, Lokanath N, Vishnu M.N, Madhusudhana CC, Saleem MTS. et al., (2012). A review
on phytochemical and pharmacological aspects of Saussurea lappa. International Journal of Review in Life Sciences.
Sharma V, Sharma R, Gautam DS. Role of Vacha (Acorus calamus Linn.) in Neurological and Metabolic Disorders: Evidence from Ethnopharmacology, Phytochemistry, Pharmacology and Clinical Study; J. Clin. Med. 2020, 9(4),
; https://doi.org/10.3390/jcm9041176
Pankaj, Aishwarya, Kumar R, Tandon R, Sharma N. An exhaustive review on pharmacological potential of Aconitum heterophyllum. Plant Cell Biotechnology and Molecularbiology, Page 280-293, 15 May 2021.
Arghavan MMR, Khazdair, Zahra SB. Experimental and clinical reports on anti-inflammatory, antioxidant and immunomodulatory effects of Curcuma longa and curcumin, an updated and comprehensive review. 19 February 2021. https://doi.org/10.1002/biof.1716.
Chander V, Aswal JS., Dobhal R, Uniyal DP. A review on Pharmacological potential of Berberine; an active component of Himalayan Berberis aristata. J Phytopharmacol, 2017 6(1), 53-58.
Pendurkar RS, Mengi SA. Antihyperlipidemic effect of aqueous extract of Plumbago zeylanica roots in diet induced hyperlipidemic rat. Pharm Biol. 2009;47(10):1004–
https://doi.org/10.1080/13880200902973779. 24. Ganie SA, Yadav SS. Holoptelea integrifolia (Roxb.) Planch: A Review of Its Ethnobotany, Pharmacology, and Phytochemistry. Hindawi Publishing Corporation, BioMed
Research International 2014, Article ID 401213, http://dx.doi.org/10.1155/2014/401213.
Shangying Ma, Wang X, Lai F, Lou C. The beneficial pharmacological effects and potential mechanisms of picroside II: Evidence of its benefits from in vitro and in vivo. Biomedicine and Pharmacotherapy, Vol.130, Oct 2021, 110421.
Choudhary MI, Naheed S, Jalil S, Alam JM, Rahman AU. Effects of ethanolic extract of Iris germanica on lipid profile of rats fed on a high-fat diet. Journal of Ethnopharmacology. Vol 98, Issue 1-2, April 2005, pages 217-220. PMID: 15849875, DOI: 10.1016/j.jep.2005.01.013
Pandey A. K. Ayurvediya roga nidana: Vol.I & II, 1st Edition 2021 in Hindi, Published by Chaukhamba Publications, 4262/3, Ansari Road, Darya Ganj, New Delhi-110002, India.
Digestion and Metabolism in Ayurveda, C. Dwarkanath – Krishnadas, Academy Varanasi, 1997.
Pandey AK, A Text book of Kayachikitsa Vol.I-IV in Hindi, 1st edition. New delhi, india: Chaukhambha Publications.
