Therapeutic Appraisal of Phalatrikadi Yoga with Lekhaniya Mahakashaya in Medoroga w.s.r. to Metabolic Syndrome: A Review.

Abstract

Santarpanottha Vikaras (diseases due to excessive nutrition) are increasing  in current era due to faulty lifestyle. Medodushti (disorders of fat  metabolism) serves as one of the important etiological factors in most of  these disorders including dyslipidaemia, obesity, metabolic syndrome etc.  Obesity and Metabolic syndrome (MS) are interconnected disorders having  global prevalence, which are associated with physiological, biochemical,  clinical and metabolic abnormalities. Both disorders directly influence the  risk of cardiovascular disease (CVD) and diabetes mellitus. MS is  considered as a first order risk factor for atherothrombotic complications.  Pharmacodynamic attributes i.e., Tikta, Katu, Kashaya Rasa, Laghu,  Ruksha, Tikshna Guna and Ushna Veerya, Katu Vipaka have individual  effect in obesity. Katu Vipaka is having more significant influence in  producing Medohara, Lekhana and Karshana karma which is important for  management of obesity. It will also help in selection of drugs for the  management of Medoroga. Overall, the drugs having dominance Kaphavata  shamaka, Dipana, Pachana (digestion), Srotoshodhana (channel cleansing),  and Medohara (lipolytic) properties are found to be effective in the  management of Medoroga w.s.r. Metabolic Syndrome. In this context,  Ayurvedic formulation is selected to laid down an emphasis on its  therapeutic potential based on Ayurvedic pharmacodynamic and  contemporary work done by the researchers of biomedical sciences.