Sebastiania Chamaelea (L.) Mull. Arg. - An Experimental Study for Analgesic Efficacy

Abstract

The recognition of pain as a pathologic phenomenon in and of itself is still up for  discussion. Despite the evidence that pain is an illness, the pathologic nature of  this condition has not yet been fully acknowledged. In order to fulfil the growing  need for pain management, this study sought to improve the native flora.  Sebastiania chamaelea (L.) Mull.Arg, is one among those indigenous flora of  Kerala that was in folklore management of ailments decades back. In the study,  the analgesic efficacy of whole-plant powder was evaluated in Wistar albino rats  using the Eddy's Hot plate method at three distinct doses (effective dose, half the  effective dose, and double the effective dose). The outcome variable under  investigation was the duration of jumping or licking paws. The drug's analgesic  activity is evidenced by the lengthening of the response time. One-way ANOVA  was performed on the collected data along with a Tukey post-hoc test. According  to the findings, the double dosage group of rats had significant analgesic effect  when compared to other dose groups and the control group at a P value < 0.005.  and the double-dose group had the longest time for reaction at the 60th minute  (p<0.0001). The powder form of the drug showed considerable analgesic action  at its double the effective dose when evaluated using the thermal model of Wistar  albino rats, also known as the Eddy's hot plate method.