Impact of "Yoga Based Lifestyle Interventions" and its Implications on Health and Disease

Authors

  • Mrithunjay Rathore Additional Professor, Department of Anatomy, AIIMS Raipur, 492099(CG) Author
  • Meghnath Verma Research Officer, CCRYN-CMBIY, AIIMS, Raipur, 492099, (CG) Author
  • Jessy Abraham Additional Professor, Department of Biochemistry, AIIMS Raipur, 492099, (CG) Author
  • Rima Dada Professor, Laboratory for Molecular Reproduction and Genetics, Department of Anatomy, AIIMS, New Delhi-110029 Author
  • Manoj Kumar Professor, Laboratory for Molecular Reproduction and Genetics, Department of Anatomy, AIIMS, New Delhi-110029 Author

DOI:

https://doi.org/10.48165/IRJAY.2023.6112

Keywords:

Yoga, Meditation, Gene expression, Biochemical Markers

Abstract

Yoga and meditation address mind and body, affecting many molecular processes like  metabolism, epigenetic, oxidative processes, and subjective well-being. In this review,  we have compiled the results of various clinical trials that have looked into the effect of  yoga-based intervention programs on gene expression changes in peripheral blood  mononuclear cells (PBMCs). Most yoga-based interventions aided in the maintenance  of genomic stability through maintenance of telomere length and showed improvement  in innate immunity. However, there is a lack of randomization and variability in the  duration of intervention programs across studies. So, future trials should focus more on  rigorous methods and reporting adequate sample size and randomization. Aim: To explores the effect of yoga on physical health through observable molecular changes in the form of differential gene expression and the molecular changes  underpinning psycho physiological benefits.Materials and Methods: we reviewed different types of Mind body interventions  (MBIs) of various observable molecular changes in the form of differential gene  expression. Result and discussion: This review adds to the ever-growing literature on the effects of  Yoga/MBIs on health and disease, specifically the changes in the regulation of gene  expression levels. Conclusion: our review article suggests that a comprehensive yoga program induces  significant gene expression changes. By adopting a yoga and meditation-based lifestyle,  we surely can slow down the pace of our biology or chronological age

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References

Buric I, Farias M, Jong J. What Is the Molecular Signature of Mind-Body Interventions? A Systematic Review of Gene Expression Changes Induced by Meditation and Related Practices. Front Immunol. 2017 Jun 16;8:670.

Abbott R, Lavretsky H. Tai Chi and Qigong for the treatment and prevention of mental disorders. Psychiatr Clin North Am. 2013 Mar;36(1):109-19.

Stahl JE, Dossett ML, LaJoie AS, et al. Relaxation Response and Resiliency Training and Its Effect on Healthcare Resource Utilization. PLoS One. 2015 Oct 13;10(10):e0140212.

Ross A, Thomas S. The health benefits of yoga and exercise: a review of comparison studies. J Altern Complement Med. 2010 Jan;16(1):3-12.

Rathore M, Trivedi S, Abraham J, Sinha MB. Anatomical Correlation of Core Muscle Activation in Different Yogic Postures. Int J Yoga. 2017 May-Aug;10(2):59-66.

Raub JA. Psychophysiologic effects of Hatha Yoga on musculoskeletal and cardiopulmonary function: a literature review. J Altern Complement Med. 2002 Dec;8(6):797- 812.

Bowers L, Douzenis A, Galeazzi GM, et al. Disruptive and dangerous behaviour by patients on acute psychiatric wards in three European centres. Soc Psychiatry Psychiatr Epidemiol. 2005 Oct;40(10):822-8.

Büssing A, Michalsen A, Khalsa SB, et al. Effects of yoga on mental and physical health: a short summary of reviews. Evid Based Complement Alternat Med. 2012;2012:165410.

Mahapure HH, Shete SU, Bera TK. Effect of yogic exercise on superoxide dismutase levels in diabetics. Int J Yoga. 2008 Jan;1(1):21-6.

Creswell JD, Irwin MR, Burklund LJ, et al. Mindfulness Based Stress Reduction training reduces loneliness and pro-inflammatory gene expression in older adults: a small randomized controlled trial. Brain Behav Immun. 2012 Oct; 26(7):1095-101.

Black DS, Cole SW, Irwin MR, Breen E, et al. Yogic meditation reverses NF-κB and IRF-related transcriptome dynamics in leukocytes of family dementia caregivers in a randomized controlled trial. Psychoneuroendocrinology. 2013 Mar; 38(3):348-55.

Bierhaus A, Wolf J, Andrassy M, Rohleder N, et al. A mechanism converting psychosocial stress into mononuclear cell activation. Proc Natl Acad Sci U S A (2003) 100(4):1920–5.

Krishna BH, Keerthi GS, Kumar CK, Reddy NM. Association of leukocyte telomere length with oxidative stress in yoga practitioners. J Clin Diagn Res. 2015 Mar;9(3): CC01-3.

Mantovani A, Allavena P, Sica A, Balkwill F. Cancer related inflammation. Nature. 2008 Jul 24; 454(7203):436- 44.

Slavich GM. Understanding inflammation, its regulation, and relevance for health: a top scientific and public priority. Brain Behav Immun. 2015 Mar; 45():13-4.

Said MA, Eppinga RN, Hagemeijer Y, et al. Telomere Length and Risk of Cardiovascular Disease and Cancer. J Am Coll Cardiol. 2017 Jul 25;70(4):506-507.

Lopizzo N, Tosato S, Begin V, et al. Transcriptomic analyses and leukocyte telomere length measurement in subjects exposed to severe recent stressful life events. Transl Psychiatry. 2017 Feb 21;7(2):e1042.

Bower JE, Irwin MR. Mind-body therapies and control of inflammatory biology: A descriptive review. Brain Behav Immun. 2016 Jan;51:1-11.

Sharma H, Sen S, Singh A, et al. Sudarshan Kriya practitioners exhibit better antioxidant status and lower blood lactate levels. Biol Psychol. 2003;63:281–91.

Sharma H, Datta P, Singh A, Sen S, et al. Gene expression profiling in practitioners of Sudarshan Kriya. J Psychosom Res. 2008 Feb;64(2):213-8.

Zope SA, Zope RA. Sudarshan kriya yoga: Breathing for health. Int J Yoga. 2013 Jan;6(1):4-10.

Qu S, Olafsrud SM, Meza-Zepeda LA, Saatcioglu F. Rapid gene expression changes in peripheral blood lymphocytes upon practice of a comprehensive yoga program. PLoS One. 2013 Apr 17;8(4):e61910.

Kumar A, Balkrishna A. To study the effect of the sequence of seven pranayama by Swami Ramdev on gene expression in leukaemia patients and rapid interpretation of gene expression. J Clin Pathol. 2009 Nov;62(11):1052-3.

Carlson LE, Beattie TL, Giese-Davis J, et al. Mindfulness-based cancer recovery and supportive expressive therapy maintain telomere length relative to controls in distressed breast cancer survivors. Cancer. 2015 Feb 1;121(3):476-84.

Lavretsky H, Epel ES, Siddarth P, Nazarian N, et al. A pilot study of yogic meditation for family dementia caregivers with depressive symptoms: effects on mental health, cognition, and telomerase activity. Int J Geriatr Psychiatry. 2013 Jan;28(1):57-65.

Rao KS, Chakrabarti SK, Dongare VS, et al. Antiaging Effects of an Intensive Mind and Body Therapeutic Program through Enhancement of Telomerase Activity and Adult Stem Cell Counts. J Stem Cells.

;10(2):107-25.

Jacobs TL, Epel ES, Lin J, Blackburn EH, et al. Intensive meditation training, immune cell telomerase activity, and psychological mediators. Psychoneuroendocrinology. 2011 Jun;36(5):664-81.

Duraimani S, Schneider RH, Randall OS, et al. Effects of Lifestyle Modification on Telomerase Gene Expression in Hypertensive Patients: A Pilot Trial of Stress Reduction and Health Education Programs in African Americans. PLoS One. 2015 Nov 16;10(11):e0142689.

Dada R, Kumar SB, Tolahunase M, et al. Yoga and Meditation as a Therapeutic Intervention in Oxidative Stress and Oxidative DNA Damage to Paternal Genome. J Yoga Phys Ther. 2015; 5:217.

Kumar SB, Yadav R, Yadav RK, Tolahunase M, and Dada R. Telomerase activity and cellular aging might be positively modified by yoga-based lifestyle intervention. The Journal of Alternative and Complementary Medicine. June 2015, 21(6): 370-372

Ornish D, Lin J, Chan JM, et al. Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study. Lancet Oncol. 2013 Oct;14(11):1112-20.

Cole SW, Yan W, Galic Z, et al. Expression-based monitoring of transcription factor activity: the TELiS database. Bioinformatics. 2005 Mar; 21(6):803-10.

Criswell JD, Irwin MR, Burklund LJ, et al. Mindfulness Based Stress Reduction training reduces loneliness and pro-inflammatory gene expression in older adults: a small randomized controlled trial. Brain Behav Immun. 2012 Oct; 26(7):1095-101

Bower JE, Ganz PA, Irwin MR, et al. Fatigue and gene expression in human leukocytes: increased NF-κB and decreased glucocorticoid signaling in breast cancer survivors with persistent fatigue. Brain Behav Immun. 2011 Jan;25(1):147-50.

Bower JE, Greendale G, Crosswell AD, et al. Yoga reduces inflammatory signaling in fatigued breast cancer survivors: a randomized controlled trial. Psychoneuroendocrinology. 2014 May;43:20-9.

Bhargava H, Metri K, Raghuram N, Ramarao NH, Koka PS. Enhancement of cancer stem cell susceptibility to conventional treatments through complementary yoga therapy: Possible cellular and molecular mechanisms. J Stem Cells. 2012;7:261–7.

Bhattacharya S, Pandey US, Verma NS. Improvement in oxidative status with yogic breathing in younghealthy males. Indian J Physiol Pharmacol. 2002;46:349–54.

Del Rio D, Stewart AJ, Pellegrini N. A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr Metab Cardiovasc Dis. 2005;15:316–28.

Epel ES, Puterman E, Lin J, et al. Meditation and vacation effects have an impact on disease-associated molecular phenotypes. Transl Psychiatry (2016) 6(8):e880.

A, Okereke OI, Yang T, Blacker D, Selkoe DJ, Grodstein F. Plasma amyloid-β as a predictor of dementia and cognitive decline: a systematic review and meta-analysis. Arch Neurol (2012) 69(7):824–31.

Baskaran A, Carvalho AF, Mansur RB, McIntyre RS. Are major depressive disorder and diabetes mellitus amyloidogenic conditions? CNS Neurol Disord Drug Targets (2014) 13(10):1667–76.

Gabelle A, Schraen S, Gutierrez LA, et al. Plasma β amyloid 40 levels are positively associated with 43. Tolahunase M, Sagar R, Dada R. Impact of Yoga and Meditation on Cellular Aging in Apparently Healthy Individuals: A Prospective, Open-Label Single-Arm Exploratory Study. Oxid Med Cell Longev. 2017;2017:9. 44. Dada T, Faiq MA, Mohanty K, Mittal D, Bhat M, Yadav RK, et al., editors. Effect of Yoga and Meditation Based Intervention on Intraocular Pressure, Quality of Life, Oxidative Stress and Gene Expression Pattern in Primary Open Angle Glaucoma: A Randomized Controlled Trial. ARVO; 2016; Seattle, Wash.

Tolahunase M, Sagar R, Khan S, Dada R. Impact of Yoga and Meditation on oxidative stress biomarkers and

Transcriptome in Major depressive disorder (MDD). JISANH. 2016;3(3):1255.

Kanherkar RR, Stair SE, Bhatia-Dey N, Mills PJ, Chopra D, Csoka AB. Epigenetic Mechanisms of Integrative Medicine. Evidence-based Complementary and Alternative Medicine: eCAM. 2017;2017:4365429.

Sengupta P, Chaudhuri P, Bhattacharya K. Male reproductive health and yoga. Int J Yoga. 2013 Jul;6(2):87- 95.

Bisht S, Faiq M, Tolahunase M, Dada R. Oxidative stress and male infertility. Nat Rev Urol. 2017 Aug;14(8):470- 485.

Rima D, Shiv BK, Bhavna Ch, Shilpa B, Saima Kh. Oxidative Stress-Induced Damage to Paternal Genome and Impact of Meditation and Yoga - Can it Reduce Incidence of Childhood Cancer? Asian Pac J Cancer Prev. 2016 Jan 9;17(9):4517-4525.

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Published

2023-01-31

Issue

Vol. 6 No. 1 (2023): International Research Journal of Ayurveda And Yoga (Jan) 2023

Section

Review Article

How to Cite

Rathore, M., Verma, M., Abraham, J., Dada, R., & Kumar, M. (2023). Impact of "Yoga Based Lifestyle Interventions" and its Implications on Health and Disease . International Research Journal of Ayurveda & Yoga, 6(1), 64-73. https://doi.org/10.48165/IRJAY.2023.6112
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