A Clinico-Pathological Study on Amlapitta w.s.r to Gastroesophageal Reflux Disease (GERD) and its Comparative Management with Narikela Khanda and Kusmanda Khanda.

Abstract

Introduction: Amlapitta described in Ayurveda classics resembles to the clinical features  of GERD. Amlapitta is more prevalent disease of Annavaha Srotasa (gastrointestinal  system) described in various classical Ayurvedic texts. Narikela Khanda and Kushmanda  Khanda are the formulations mentioned in Bhaisajya Ratnavali indicated for management  of Amlapitta.  Aims: To evaluate the effect of Narikela Khanda and Kushmanda Khanda in management  of Amlapitta.  Materials and methods: A non-randomized, single-armed, open-labeled clinical trial was  conducted in 30 patients having classical symptoms of Amlapitta, administered with 10gm  of Narikela Khanda & 10gm of Kushmanda Khanda twice a day after food for 30 days  respectively. The assessment was done based on subjective parameters, i.e.,  Amlodgara (sourbelching), Daha (heartburn), Gaurava (heaviness), Utklesha (nausea), A vipaka (indigestion) and Aruchi (loss of appetite) were taken into consideration. The  subjective parameters were analysed by Wilcoxon-W test and p-value.  Result- In Group A, 6.67% patients had marked improvement, while 73.33% patients had  moderate improvement and 20.00% mildly improved. In Group B, 60.00% patients had  moderate improvement and 40% marked improved. In both the Group the result was  statistically significant, but improvement was noticed more in Group- B.  Conclusion- On comparison between two groups, Kushmanda Khanda have shown more  effect than Narikela Khanda. No adverse effects were noticed during clinical trial in both  groups.