Clinico-Pathological Study of Phalatrikadi Ghana Vati and Vasadi Ghana Vati on Kamala w.s.r to Jaundice

Abstract

Introduction: Kamala, described in Ayurveda classics resembles to the clinical features of  Jaundice. Liver i.e. Yakrita is the Moolasthana of Pachak Pittas, Raktavaha strotasa. Which  we can correlate with Hepatobiliary system. Disturbance or diseases of hepatic system leads to  mortality all the way through failure of remaining systems of our body. Kamala is one of the  most important and specified disease of Yakrita which can be correlated with Jaundice.  Materials and methods: A clinical study on 30 Kamala patients, (15 patients each in Group-A and Group-B) were registered from OPD and IPD of Govt. Ayurvedic College and Hospital,  Balangir, Odisha. The patients presented with the Subjective Parameters of Haridra netra, twak,  nakha and mukha (yellow discoloration of eye, skin, nail bed and oral mucosa), Rakta pita  purisha and mutra, Bheka varna , Hatendriya, Daha , Avipaka Daurbalya, Sadana, Aruci,  Karshana and Objective parameters as LFT, Urine Bile Salt/Bile Pigment, Stool examination  and CBC were selected for clinical study. Group-A patients were treated with Phalatrikadi  Ghana Vati (500mg) and Group-B patients with Vasadi Ghana Vati (500 mg) thrice daily after  food with honey or luke warm water orally for 15 days respectively. The patients were assessed  at 10 days interval up to 30 days in order to find the efficacy of both the trial drugs. The  subjective and objective parameters were analysed statistically by Wilcoxon-W test and p-value.  Observation and result: The Statistically significant (P<0.05) result was revealed in both  Group-A and Group-B but improvement was noticed more in Group-A.  Conclusion: -The overall study revealed that the trial on Phalatrikadi Ghana Vati, i.e., Group A showed more efficacy than Vasadi Ghanavati i.e, Group-B. The composition of Phalatrikadi  Ghana Vati helped more to develop the body immunity as well as maintain the LFT parameters  rather than Vasadi Ghanavati. No adverse effects was noticed during clinical trial in both  groups.