Standardization of Shatpala Ghrita w.s.r Pharamaceutico-Analytical and Antioxidant Study

Abstract

Sneha kalpana is one of the unique and commonly prescribed Ayurvedic dosage form in day  to day practice having increase potency, palatability, shelf life etc. Although lots of verities of  Snehas are described in Ayurvedic texts, the most common amongst them are Taila & Ghrita  kalpana. It is a pharmaceutical process to prepare oleaginous medicament from the substances  like Kalka, Sneha Dravya and Drava Dravya in specific proportion by subjecting to unique  heating pattern and duration, to fulfil certain parameters according to need of therapeutics (i.e.  Mridu, Maddhya & Khar). Sneha Siddha (fat soluble) drugs have better pharmacokinetic  action in comparison to other dosage forms, because the use of Ghrita as a base is presumably  to extract or hold lipid soluble active ingredients from the herbal drugs used and these lipid  soluble substances readily permeate into the bio membrane of cells due to its lipid nature. The  conceptual study suggests that Shatapala Ghrita is used to treat Jwara mainly Vata and Kapha  Dosha predominant. Standardization is the process of developing and agreeing upon technical  standards and provides numerical value which quantifies the parameter and thus denotes the  quality of formulations. Murchana performed on Go-Ghrita makes it a better medium for the  solubility of the drug and imparts all the specific properties to the Ghrita which can be used  to increase the efficacy of the drugs. Hence, it can be inferred that the medicated Ghrita should  be prepared by taking the Murchhita Ghrita as ingredient rather without Ghrita Murchhana.  In so many Ghrita kalpanas, Shatapala Ghrita is a ghee based Ayurvedic formulation  described in Samhitas and various Rasa texts with different name and slightly changes in  contents. It has broad indication such as enlarge spleen (splenomegaly), Vishamajwara,  Mandaagni, Rajyakshma etc.