A Comparative Clinico-Pathological Study On CRP Positive Patients W.S.R. To Amavata (Rheumatoid Arthritis) And Its Management With Vatari Guggulu And Pathyadi Churna

Abstract

Introduction- C-Reactive Protein (CRP) is an acute-phase of inflammatory protein, a  highly conserved plasma protein that is named for its reaction with the capsular C-polysaccharide  of Pneumococcus. It is an Annular (Ring-shaped) Pentameric protein found in blood plasma, whose circulating  concentration rise in response to inflammation and of hepatic origin that increases interleukin-6 secretion  by macrophages and T-cells. Due to this type of inflammatory changes there are stiffness, Pain, Swelling of  joints along with generalized symptoms of fever etc. present in the disease like Amavata (Rheumatoid Arthritis). Materials and methods- 30 patients of Group-A (15) and Group-B (15) patients were registered from OPD  and IPD of Govt. Ayurvedic College & Hospital, Balangir presented with Subjective Parameter as Sandhi Ruja,  Sandhi Shotha, Sandhi Stabdhata, Jwara, Aruchi and Daurbalya and Objective Parameter as CRP>6mg/L, ESR,  Hb%, DLC,TLC and Lipid profile test. After diagnosis they were under trial with Ayurvedic formulations of  Vatari guggulu given 500mg thrice daily after food in Group A and Pathyadi Churna given 5gm twice daily  after food with ushnajala for a period of 30 days with respectively. The subjective and objective parameters  were assessed in 10 days interval to interpret the result by statistical evaluation. Observation and results:- It has been observed that the result of trial drug Group-A patients is Significant  (p<0.05) to reduce both Subjective and Objective parameter after 30 days of treatment as campair to Group-B  patients. Conclusion- CRP positive patients suffered from Amavata (Rheumatoid Arthritis) showed Significant  improvement after receiving the Ayurvedic formulation ‘Vatari Guggulu’ in this study. No adverse effect was  observed.