Physiological Effects of Yoga and Pranayama on Serum Adipokines,  Lipoprotein (a), Thyrotropin Levels, and Blood Pressure among  Obese Hypothyroid Patients with Hypertension

Smitha R Varne; P A  Balaji

doi:10.48165/IRJAY.2023.6802

Authors

Smitha R Varne Consultant Yoga, Naturopathy and Integrated Physician, Preksha Wellness and Yoga Centre, Rajiv Gandhi university of Health Sciences, Bangalore, India. Author
P A Balaji Consultant Physician and ESH Hypertension Specialist, Sakaria Hospital and Preksha Wellness and Yoga Centre, Rajiv Gandhi University of Health Sciences, Bangalore, India. Author

DOI:

https://doi.org/10.48165/IRJAY.2023.6802

Keywords:

Adipokines, Hypertension, Hypothyroidism, Obesity, Pranayama, Yoga

Abstract

Background: The trio of obesity, hypothyroidism, and hypertension can act as a strong synergistic risk factor through parameters, like elevated serum leptin and lipoprotein (a) and decreased adiponectin levels, for the development of atherosclerotic diseases. Very few studies have focused on the effects of yoga/pranayama on these parameters among obese hypothyroid patients with hypertension. Hence, the present research work was carried out to evaluate the effects of 6 months of yoga and pranayama practices on these parameters. Materials and Methods: The present interventional study was conducted involving 20 obese hypothyroid patients with hypertension, their baseline values of serum adipokines, lipoprotein (a), thyrotropin-releasing hormone (TRH) levels, blood pressure (BP), and body mass index (BMI) were recorded and they were subjected to 6 months of yoga/ pranayama and the same were recorded at the end of 6 months, and data were statistically analyzed. Results: There was a statistically significant reduction (P < 0.01) between baseline versus after 6 months in parameters such as serum leptin (23.94 ± 12.96 vs. 11.88 ± 10.32 ng/mL); serum lipoprotein (a) (28.45 ± 3.12 vs. 12.98 ± 3.56 mg/dL); BMI (29.42 ± 3.01vs. 25.36 ± 2.41 kg/m2); and significant improvement (P < 0.01) in serum adiponectin (3.44 ± 2.32 vs. 8.86 ± 4.88 ug/mL); systolic BP (147.24 ± 7.39 vs. 126.88 ± 6.34 mmHg); diastolic BP (95.76 ± 6.32 vs. 82.04 ± 4.56 mmHg); and TSH (13.41 ± 3.34 vs. 2.83± 2.62 mIU/L). Conclusion: Yoga and pranayama practice for 6 months resulted in beneficial effects such as reduction of serum leptin, lipoprotein (a) levels, BMI, BP, and improved adiponectin levels and thyroid functions among obese hypothyroid patients with hypertension.

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References

Kinlen D, Cody D, O’Shea D. Complications of obesity. QJM 2018;111:437-43.

Kirichenko TV, Markina YV, Bogatyreva AI, Tolstik TV, Varaeva YR, Starodubova AV. The role of adipokines in inflammatory mechanisms of obesity. Int J Mol Sci 2022;23:14982.

Zorena K, Jachimowicz-Duda O, Ślęzak D, Robakowska M, Mrugacz M. Adipokines and obesity. Potential link to metabolic disorders and chronic complications. Int J Mol Sci 2020;21:3570.

Chaldakov GN, Fiore M, Stankulov IS, Hristova M, Antonelli A, Manni L, et al. NGF, BDNF, leptin, and mast cells in human coronary atherosclerosis and metabolic syndrome. Arch Physiol Biochem 2001;109:357-60.

Mraz M, Haluzik M. The role of adipose tissue immune cells in obesity and low-grade inflammation. J Endocrinol 2014;222:R113-27. 6. Reyes-Soffer G, Ginsberg HN, Berglund L, Duell PB, Heffron SP, Kamstrup PR, et al. Lipoprotein(a): A genetically determined, causal, and prevalent risk factor for atherosclerotic cardiovascular disease: A scientific statement from the American heart association. Arterioscler Thromb Vasc Biol 2022;42:e48-60.

Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol 2011;29:415-45.

Ouchi N, Walsh K. Adiponectin as an anti-inflammatory factor. Clin Chim Acta 2007;380:24-30.

Rosenbaum M, Hirsch J, Murphy E, Leibel RL. Effects of changes in body weight on carbohydrate metabolism, catecholamine excretion, and thyroid function. Am J Clin Nutr 2000;71:1421-32.

Sanyal D, Raychaudhuri M. Hypothyroidism and obesity: An intriguing link. Indian J Endocrinol Metab 2016;20:554-7. 11. Laurberg P, Knudsen N, Andersen S, Carlé A, Pedersen IB, Karmisholt J. Thyroid function and obesity. Eur Thyroid J 2012;1:159-67.

Danforth E Jr., Horton ES, O’Connell M, Sims EA, Burger AG, Ingbar SH, et al. Dietary-induced alterations in thyroid hormone metabolism during overnutrition. J Clin Invest 1979;64:1336-47.

Landsberg L, Aronne LJ, Beilin LJ, Burke V, Igel LI, Lloyd-Jones D, et al. Obesity-related hypertension: Pathogenesis, cardiovascular risk, and treatment: A position paper of The Obesity Society and the American Society of Hypertension. J Clin Hypertens (Greenwich) 2013;15:14-33.

Garrison RJ, Kannel WB, Stokes J 3rd, Castelli WP. Incidence and precursors of hypertension in young adults: The Framingham Offspring Study. Prev Med 1987;16:235-51.

Faulkner JL, Belin de Chantemèle EJ. Sex differences in mechanisms of hypertension associated with obesity. Hypertension 2018;71:15-21. 16. Shariq OA, McKenzie TJ. Obesity-related hypertension: A review of pathophysiology, management, and the role of metabolic surgery. Gland Surg 2020;9:80-93.

Asvold BO, Bjøro T, Nilsen TI, Vatten LJ. Association between blood pressure and serum thyroid-stimulating hormone concentration within the reference range: A population-based study. J Clin Endocrinol Metab 2007;92:841-5.

Streeten DH, Anderson GH Jr., Howland T, Chiang R, Smulyan H. Effects of thyroid function on blood pressure. Recognition of hypothyroid hypertension. Hypertension 1988;11:78-83.

Drivsholm A, Lund MA, Hedley PL, Jespersen T, Christiansen M, Hansen T, et al. Associations between thyroid-stimulating hormone, blood pressure and adiponectin are attenuated in children and adolescents with overweight or obesity. J Pediatr Endocrinol Metab 2019;32:1351-8.

Venkatesh T, Ravikumar I, Mani TA. Development of a yoga module for hypothyroidism. J Clin Diagn Res 2021;15:LC25-31. 21. Supriya R, Yu AP, Lee PH, Lai CW, Cheng KK, Yau SY, et al. Yoga training modulates adipokines in adults with high-normal blood pressure and metabolic syndrome. Scand J Med Sci Sports 2018;28:1130-8.

Lee JA, Kim JW, Kim DY. Effects of yoga exercise on serum adiponectin and metabolic syndrome factors in obese postmenopausal women. Menopause 2012;19:296-301.

Kiecolt-Glaser JK, Christian LM, Andridge R, Hwang BS, Malarkey WB, Belury MA, et al. Adiponectin, leptin, and yoga practice. Physiol Behav 2012;107:809-13.

Nilakanthan S, Metri K, Raghuram N, Hongasandra N. Effect of 6 months intense Yoga practice on lipid profile, thyroxine medication and serum TSH level in women suffering from hypothyroidism: A pilot study. J Complement Integr Med 2016;13:189-93.

Carei TR, Fyfe-Johnson AL, Breuner CC, Brown MA. Randomized controlled clinical trial of yoga in the treatment of eating disorders. J Adolesc Health 2010;46:346-51.

Nagarathna R, Kumar S, Anand A, Acharya IN, Singh AK, Patil SS, et al. Effectiveness of yoga lifestyle on lipid metabolism in a vulnerable population-a community based multicenter randomized controlled trial. Medicines (Basel) 2021;8:37.

Shantakumari N, Sequeira S, El Deeb R. Effects of a yoga intervention

on lipid profiles of diabetes patients with dyslipidemia. Indian Heart J 2013;65:127-31.

Abbott MJ, Killian TJ, Walsh CS, Yim VT. The effects of Ashtanga yoga on circulating adipokines and inflammatory associated miRNAs. FASEB J 2018;32:Lb267.

Vinudha S. Efficacy of Ujjayi Pranayama on Hypothyroidism in Adults: A Randomized Controlled Trial. Master Thesis, Government Yoga and Naturopathy Medical College, Chennai, India; 2019. Available from: https://repository-tnmgrmu.ac.in/10717 [Last accessed on 2023 Aug 02].

Shetty GB, Shetty B, Shetty P. Effect of short-term naturopathy and yoga intervention on anthropometric variables, lipid profile and thyroid profile in obese hypothyroid patients: A randomized controlled trial. Int J Basic Clin Pharmacol 2020;9:247-53.

Dinesh R, Sandeep KS, Rachana J, Rajeev KS. Method of Ujjayi pranayama in the management of hypothyroidism. World J Pharm Med Res 2020;6:213-6.

Balaji PA, Varne SR. High-sensitive CRP levels, Plasma renin activity and blood pressure among Hypertensive patients practicing Yoga exercises. Indian J Clin Anat Physiol 2017;4:431-4.

Thiyagarajan R, Pal P, Pal GK, Subramanian SK, Trakroo M, BobbyZ, et al. Additional benefit of yoga to standard lifestyle modification on blood pressure in prehypertensive subjects: A randomized controlled study. Hypertens Res 2015;38:48-55.

Apar AS, Raghavendra BR, Manjunath NK. Effects of yogic breath regulation: A narrative review of scientific evidence. J Ayurveda Integr Med 2019;10:50-8.

Top 8 Yoga Poses and Pranayama for Thyroid Problems. Available from: https://www.curejoy.com/content/yogaand-pranayama-for thyroid-problems/#sarvangasana [Last accessed on 2023 Jul 19].

Selvamurthy W, Sridharan K, Ray US, Tiwary RS, Hegde KS, Radhakrishan U, et al. A new physiological approach to control essential hypertension. Indian J Physiol Pharmacol 1998;42:205-13.

Goyal R, Lata H, Walia L, Narula MK. Effect of pranayama on rate pressure product in mild hypertensives. Int J Appl Basic Med Res 2014;4:67-71.

Balaji PA, Smitha RV. Integrated review of management of hypertension by lifestyle changes, yoga, exercise, acupressure, plant/ herbal and allopathic medications, and newer interventions. Indian J Integr Med 2023;3:1-8.

Balaji PA, Varne SR, Ali SS. Physiological effects of yogic practices and transcendental meditation in health and disease. North Am J Med Sci 2012;4:442-8.

Ghazvineh D, Daneshvar M, Basirat V, Daneshzad E. The effect of yoga on the lipid profile: A systematic review and meta-analysis of randomized clinical trials. Front Nutr 2022;9:942702.

Yazdanparast F, Jafarirad S, Borazjani F, Haghighizadeh MH, Jahanshahi A. Comparing between the effect of energy-restricted diet and yoga on the resting metabolic rate, anthropometric indices, and serum adipokine levels in overweight and obese staff women. J Res Med Sci 2020;25:37.