Screening Of Free Radical Scavenging Activity and Immuno-Modulatory Effect Of Jwaramurarirasa

Abstract

Jwaramurari Rasa is one of the herbo mineral formulation having property of Rasayana (rejuvenation therapy). Recent study shown the presence of phytochemical like alkaloids,  carbohydrates, steroids, flavonoids, proteins, saponins, and tripenoids. Hence antioxidant and  immunomodulatory activity are expected with Jwaramurari Rasa. In this regard to provide evidence to establish  the facts mentioned in classics an attempt was made to assess the free radical scavenging activity of  Jwaramurari Rasa. Jwaramurari Rasa was subjected for screening of free radical scavenging activity by  Superoxide dismutase (SOD), Catalase, Glutathione, Malondialdehyde (MDA) test. Immunomodulatory  activity by phagocytosis, candidacidal assay, neutrophil locomotion chemotaxis, and Nitrobluete trazolium (NBT) test. 5%, 12.5%, 25%, 50% and 100% concentration of the samples were used. Jwaramurari Rasa has  shown significant immunomodulatory activity. 100% (95%) solution of Jwaramurari Rasa has shown highly  significant result with NBT test stimulation of neutrophils than control. In candidacidal activity of Jwaramurari  Rasa with100% was highly significant. Jwaramurari Rasa has shown significant results with Candidacidal,  Phagocytosis and Chemotaxis than control.