Jeevaniya Mahakashay And Its Immunomodulator Effect: A Review Article

Authors

  • Dhanraj Nagar Associate Professor , Department of Samhita Siddhant , Kalawati Ayurvedic Medical College & Hospital ,Gorha, Kasganj(UP), India Author
  • Manoj Kumar Sharma Professor, Department of Dravyaguna, Kalawati Ayurvedic Medical College &Hospital ,Gorha, Kasganj(UP), India Author

DOI:

https://doi.org/10.48165/

Keywords:

Shatavari, Vidarikanda, Ashwagandha, Mudgaparni, Mashaparni, Jeevanti, Yashtimadhu, HIV, Immunomodulator

Abstract

 India has the third largest HIV in the year 2016 and 2nd largest in SARS COVID 19 in the year  2020 of epidemic in the world.In HIV prevalence in India was an estimated 0.3%. This equates to 2.1 million people  living with and COVID 19 cases prevalance are .586% which is equates to 8.0 milion people living with SARS  COVID19 infection . HIV as well as COVID 19 infections affects multisystem, chiefly the Immune System which  can be corrected to OjaKhasya Rasayana Chikitsa is the frontline therapy employed to treat Ojas disorder. For the  process of rejuvenation, Ayurveda has described a unique therapy-Rasayana therapy. Drugs described under Rasayana act on Agni, Dhatu and Srotas level and help in formation of prashasta dhatus maintaining a perfect  equilibrium of all the doshas and dhatus. Jeevaniyagana is mentioned in Charak Samhita sutrasthana chapter fourth Shad virechanashatashritiyaadhyay. Charakokta Jeevaniya Mahakashay- Jeevak, Rishabhaka, Meda, Mahameda,  Kakoli, Ksheerakakoli, Mudgaparni, Mashaparni, Jeevanti, Madhuk. Detail usage of the individual drugs of  Jeevaniyagana has been mentioned in the article and its role as immunomodulator has been discussed. Jeevaniyagana now a days used as-Shatavari, Vidari, Ashwagandha, Mudgaparni, Mashaparni, Jeevanti, and  Madhuk. 

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References

Prof.K.R. Srikanth Murthy, Bhavaprakash of Bhavamishra, Haritakyadivarga, volume 1 Choukhamba Krishandas Academy Varanasi Edition Reprint 2004, P 181 2) Gogte VM. Ayurvedic pharmacology and therapeutic uses of medicinal plants. Mumbai: SPARC; 2000.

Frawley D. Ayurvedic healing-a comprehensive guide. Delhi: Motilal Banarsidass Publishers Private Limited; 1997.

Sharma RK, Dash B. Charakasamhita-text with english translation and critical exposition based on Chakrapani Datta's Ayurveda dipika. India: Chowkhamba Varanasi; 2003. 5) Garde GK, Vagbhat S. Marathia translation of vagbhat'sastangahridya. Uttarstana: AryabhushanaMudranalaya; 1970. pp. 40–48.

Atreya . Ayurvedic healing for women. York: Samuel Weiser Inc; 1999. 7) Srikantha MKR. Appendix and indices. Varanasi: Krishnadas Academy; 1997. 8) Sharma PV, Charaka S. Chaukhambhaorientalis. India: Varanasi; 2001. pp. 7–14. 9) Sairam KS, Priyambada NC, Goel RK. Gastroduodenal ulcer protective activity of Asparagus racemosus. An experimental, biochemical and histological study. J Ethnopharmacol. 2003;86(1):1–10.

Kamat JP, Boloor KK, Devasagayam TP, Venkatachalam SR. Antioxdant properties of Asparagus racemosusagainst damagedinduced by gamma radiation on rat liver mitochondria. JEthanopharmacol. 2000;71:425–435.

Dahanukar S, Thatte U, Pai N, Mose PB, Karandikar SM. Protective effect of Asparagus racemosus against induced abdominal sepsis. Indian Drugs. 1986;24:125–128.

Thatte U, Chhabria S, Karandikar SM, Dahanukar S. Immunotherapeutic modification of E. coli induced abdominal sepsis and mortality in mice by Indian medicinal plants. Indian Drugs. 1987;25:95–97

Vaidyaratnam P.S.: Indian Medicinal Plants – A compendium of 500 species, Vol. 4, Orientlongman publishing, Kottakkal: 391-395 (1997).

Vijay Vitthal Bhagat, Yogesh T. Kotangale and M.V.Rampurkar, To Study The Brimhan Siddhant on the Basis of Efficacy of Vidarikand on KarshyaVyadhi, IAMJ: Volume 3; Issue 5; May–2015

Akhilesh K. Tripathi and Seema Kohli, Anti-Diabetic Activity and Phytochemical Screening of Crude Extracts of Pueraria Tuberosa DC. (FABACEAE) Grown in India on STZ -Induced Diabetic Rats Asian J. Med.Pharm. Res., 3(3): 66-73, 2013

)Amal, K. Maji, Subhadip Mahapatra And Debdulal Banerjee. In-Vivo Immunomodulatory Potential of Standardized Pueraria Tuberosa Extract and its Isoflavonoids, International Journal of Pharmacy and Pharmaceutical Sciences, Vol 6, Issue 1, 2014

Pandey, N., Chaurasia, J.K., Tiwari, O.P. and Tripathi, Y.B.: Food Chem., 105 (1): 219- 222 (2007).

S. K. Vermal, V. Jain, A. Vyas and D. P. Singh Protection Against Stress Induced Myocardia Ischemia by Indian Kudzu (Pueraria Tuberosa) – A Case Study, Journal of Herbal Medicine and Toxicology 3 (1) 59-63 (2009).

RN. Mishra The Vajikaran (Aphrodisiac) Formulations in Ayurved INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY IJRPC 2012, 2(1).

N.S. Chauhan,Vikas Sharma, Mayank Thakur, Alexandra C. H. F. Sawaya, V. K. Dixit. PuerariatuberosaDC Extract Improves Androgenesis and Sexual Behavior via FSH, LH Cascade. The Scientific WorldJournal, Volume 2013..

N. Venkata Rao et.al. Nootropic activity of tuber extracts of Pueraria tuberosa, Indian Journal of Experimental Biology, Vol. 46 Aug 2008 p-591.

Nidhi Pandey, Durgavati Yadav, Vivek Pandey, Yamini BTripathi. Anti-inflammatory effect of Puerariatuberosaextracts through improvement in activity of red blood cell anti-oxidant enzymes, AYU Year : 2013,Vol: 34, Issue : 3, p. 297-301

Weiner, M.A, Weiner.J Ashwagandha (India ginseng). In: Herbs that Heal. Mill Valley, CA: Quantum Books,70–72;1994.

S. Sharma, S. Dahanukar, S.M. Karandikar. Effects of long-term administration of the roots of ashwagandha and shatavari in rats. Indian Drugs. 1985;133–139.

Budhiraja RD, Sudhir S. Review of biological activity of Withenolides (Antibacterial Antitumor, Immunomodulating, Anti-inflammatory and insect anti feedcent). J Sci Ind Res. 46, 488-91.

Chopra, R.N. Glossary of Indian Medicinal Plants. New Delhi: Academic Publishers India; 1994.

Glotter E, Kirson I, Abraham A, Lavie D. Constituents of Withania somnifera Dun—13. The withanolides of chemotype III. Tetrahedron. 1973;29(10):1353–1364.

Devi PU, Sharada AC, Solomon FE. Antitumor and radios ensitizing effects of Withaniasomnifera(Ashwagandha) on a transplantable mouse tumor, Sarcoma- 180. Indian J Exp Biol. 1993;31(7):607-11

"Withaniasomnifera". Alternative Medicine Review. FindArticles.com. 13 Oct. 2008.

Ziauddin M, Phansalkar N, Patki P, Diwanay S, Patwardhan B. Studies on the immunomodulatory effect of Asgandh. J Ethnopharmacol. 1996;50(2):69-76

Davis L, Kuttan G. Suppressive effect of cyclophosphamideinduced toxicity by Withaniasomnifera extract in mice. J Ethnopharmacol. 1998;62(3): 209-214

)Kuttan G. Use of WithaniasomniferaDunal as an adjuvant during radiation therapy. Indian J Exp Biol.1996;34 (9):854-856.

Kumar, S (2001). Flora of Haryana, Bishen Singh Mahinder Pal Singh, Dehradun, pp130

A n o n ( 2 0 0 5 ) . M e d i c i n a l P l a n t Resources of South-West Bengal, Research Wing, Directorate of Forests. Saraswaty Press Ltd. (Government of West Bengal Enterprise), Kolkata, pp182.

Warrier KR: Arogyakalpadruma. Samrat Publishers, Thrissur, Edition 1, Volume. 1, 2011: 448-455.

K R Kirtikar and B D Basu, Indian Medicinal plants, Vol-1, 2nd edition. Dehra Dun. Shiva offset Press; 1991. p 774-775

Dr. N.N.Mehrotra&Vd.SanjeevK.Ojha,AyurvedicRasayana Therapy and Rejuvenation (Kaya Kalp). In:Sheela Tandon and V.K.Vohra,(eds). Ageing. Documentation and Library Services, Central Drug Research Institute, Lucknow. Current R&D Highlights, Dr. P.KRoy; Jan-Mar2006.p 06-08.

)Kirtikar KR, Basu BD. Indian Medicinal Plants, International Book Publisher, Dehradun, 1993; (2): 898-900]

)Bhatt T, Jain V, Jayathirtha MG, Banerjee G, Mishra SH. In vitro regeneration of roots of Phyla nodiflora and Leptadenia reticulata, and comparison of roots from cultured and natural plants for secondary metabolites. Indian J. Exp. Biol, 2006; 40: 1382–1386

) Kumari BP, Reddy RM, Veena BM, Babu TM, Ranganayakul D. Antiepileptic activity and Neuropharmacological screening of methanolic extract of Leptadenia reticulata against different experimental models, J. of Adv. in Drug Res, 2010; (1): 1-9.

)Padmalatha K, Venkataraman BV, Roopa R, Antianaphylactic effect of DLH-3041 (polyherba formulation) on rat mesenteric mast cell degranulation, Ind. J. Pharmacol, 2002; 34: 119-122.

)Kalidasa C, Glory M, Francis B, Manickam V S. Antibacterial activity of Leptadenia reticulata (Retz) Wight and Arn. (Asclapiadaceae), Ancient Sci of life, 2009; 28(4): 10-12

)Girishkumar, V.; Sreepriya, M.S.; Praveenkumar, S.; Bali, G.; Jagadeesh, M.S. Modulating effect of Leptadenia

reticulata (Retz)Wight &Arn against chromate (VI)-induced immunosuppression and oxidative stress onmouse splenic lymphocytes and bone marrow derived macrophages. J. Ethnopharmacol. 2010, 131, 505–508

)Pravansha, S.; Thippeswamy, B.S.; Veerapur, V.P. Immunomodulatory and antioxidant effect of Leptadenia reticulata leaf extract in rodents: Possible modulation of cell and humoral immune response. Immunopharm. Immunot. 2012, 34, 1010–1019. [CrossRef] [PubMed

Tamir, S.; Eizenberg, M.; Somjen, D.; Izrael, S.; Vaya, J. (2001). “Estrogen-like activity of glabrene and other constituents isolated from licorice root”. The Journal of Steroid Biochemistry and Molecular Biology., 78(3):291-298.

Chien, CF; Wu, YT; Tsai, TH (January 2011). “Biological analysis of herbal medicines used for the treatment of liver diseases.” Biomedical chromatography., 25(1-2): 21-38. 47) Yasui, S; Fujiwara, K; Tawada, A; Fukuda, Y; Nakano, M; Yokosuka, O (December 2011). “Efficacy of intravenous glycyrrhizin in the early stage of acute onset autoimmune hepatits.”. Digestive Diseases and Sciences., 56(12): 3638-47.

Shibata, S (October 2000). “A drug over the millennia: pharmacognosy, chemistry, and pharmacology of licorice.” YakugakuZasshi., 120(10): 849-62.

Database on Medicinal Plants Used in Ayurveda, Published by The central council of Research in Ayurveda & Siddha, New Delhi, Year of publication 2001, Volume 3,pp.561 50 ) Immunity (medical) [Internet]. 2013 [updated 2013 Nov 4; cited 2013 Nov 5].Available from: http://en.wikipedia.org/wiki/Immunity

)Gulati K, Ray A, Debnath PK and Bhattacharya SK: Immunomodulatory Indian medicinal plants. Journal of Natural Remedies2002; 2(2):121-131

)Masihi KN: “Fighting infection using immunomodulatory agents.” Expert Opin Biol Ther 2001 Jul;1(4):641–53.

Rajagopala S, Ashok BK and Ravishankar B: Immunomodulatory activity of VachadhatryadiAvaleha in albino rats. Ayu. 2011 Apr-Jun; 32(2):275–278 54) Tripathi JS, Singh RH: The Concept and Practice of Immunomodulation in Ayurveda and the Role of Rasayanas as Immunomodulators. Ancient Science of Life 1999 Jul, Aug, Sep, Oct; 19(1&2):59-63.

Patwardhan B, Warude D, Pushpangadan P and Bhatt N: Ayurveda and traditional Chinese medicine: A comparative overview. Evid Based Complement Alternat Med. 2005; 2:465–73. 56) Singh RH, Udupa KN. Bhattacharyaa SK and Muruganandam AV: Clinical and experimental studies on Rasayana drugs and Rasayana therapy. Adaptogenic activity of Withaniasomnifera - an experimental study using a rat model of chronic stress. Pharmacol Biochem Behav. 2003; 75:547–55.

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Published

2020-11-30

Issue

Vol. 3 No. 11 (2020): International Research Journal of Ayurveda and Yoga (Nov) 2020

Section

Review Article

How to Cite

Nagar, D., & Sharma, M. K. (2020). Jeevaniya Mahakashay And Its Immunomodulator Effect: A Review Article. International Research Journal of Ayurveda & Yoga, 3(11), 75-90. https://doi.org/10.48165/
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